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Brenzavvy vs Farxiga for T2D; PFAS in Seafood; 100 Deaths Linked to GLP-1 Drugs?

— News and commentary from the endocrinology world

MedpageToday
Endo Break over a computer rendering of a man with illustrated body organs.

Bexagliflozin (Brenzavvy) and dapagliflozin (Farxiga) induced similar HbA1c reductions over 24 weeks in a head-to-head in Chinese adults with type 2 diabetes on metformin. (Journal of Diabetes)

An anti-counterfeit firm reported more than 250 websites for weight loss and diabetes. (Reuters)

Eating seafood may than previously expected. "Our recommendation isn't to not eat seafood -- seafood is a great source of lean protein and omega fatty acids. But it also is a potentially underestimated source of PFAS exposure in humans," said study author Megan Romano, PhD, of Dartmouth University's Geisel School of Medicine in Lebanon, New Hampshire, in a statement. (Exposure and Health)

have been linked to GLP-1 receptor agonists, according to a Daily Mail analysis of data from the FDA Adverse Event Reporting System. Most deaths involved gastrointestinal adverse events.

Vosoritide (Voxzogo) increased annualized growth velocity by 2.26 standard deviations and height by 0.36 standard deviations among in a phase II trial. Efficacy was similar to what's been reported in kids with achondroplasia, for which the injectable was approved in 2021. (eClinicalMedicine)

The U.S. Supreme Court allowed Idaho to temporarily enforce a for most minors. (CNN)

In women over 65, certain types of were linked with reductions in the risks for mortality, cancer, and cardiovascular diseases when compared with no hormone use or discontinuation: using low rather than medium or high doses, vaginal or transdermal rather than oral preparations, and with E2 rather than conjugated estrogen. (Menopause)

Moderate to vigorous aerobic physical activity in the evening was associated with the for people with obesity. (Diabetes Care)

AstraZeneca's modeling study IMPACT CKD projected that 16.5% of the population across eight countries by 2032.

Pressure to lose weight from family during adolescence may have lasting effects on later in life. (Lancet Regional Health Europe)

  • author['full_name']

    Kristen Monaco is a senior staff writer, focusing on endocrinology, psychiatry, and nephrology news. Based out of the New York City office, she’s worked at the company since 2015.