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Ryan Reynolds' Colonoscopy; NASH Drug Passes Phase II Test; New Drug Target in IBD?

— News and commentary from the world of gastroenterology and hepatology

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Gastro Roundup over a computer rendering of an endoscope.

In an effort to shine a light on the importance of colorectal cancer screening, movie-star Ryan Reynolds . (GMA)

The phase IIb Harmony study of met its primary and secondary histological endpoints, demonstrating improvements in fibrosis stage and NASH resolution with two doses of the investigational drug versus placebo, Akero Therapeutics announced.

Also in NASH, researchers identified liver stiffness thresholds on vibration-controlled transient elastography for in those with advanced fibrosis. (Gut)

Pre-emptive transjugular intrahepatic portosystemic shunt was compared to endoscopic treatment in high-risk patients with cirrhosis and variceal bleeding who present with hepatic encephalopathy. (Gut)

In Wilson's disease patients with chronic liver disease on chelation therapy, does having just portend worse prognosis? (Clinical Gastroenterology and Hepatology)

A third dose of COVID vaccine , though less so for those taking infliximab (Remicade) or tofacitinib (Xeljanz), according to a U.K. study. (Lancet Gastroenterology & Hepatology)

Persistent fibrinolysis resistance is a predictor of . (American Journal of Surgery)

An online interactive tool for patients with non-alcoholic fatty liver disease, and may be useful for promoting disease awareness. (JAMA Network Open)

Takeda said it ; the personalized prognostic tool can predict the risk of developing Crohn's disease-related complications within 3 years.

A within the gut may be responsible for preventing inflammation in IBD, according to early research, offering a potential new drug target for treatment. (Cell Reports)

Contrary to common practice, elective hernia repair surgery may be favorable for , an analytical modeling study suggested. (JAMA Network Open)

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    Zaina Hamza is a staff writer for MedPage Today, covering Gastroenterology and Infectious disease. She is based in Chicago.