MRD Tied to Allo-Transplant Benefit in NPM1-Mutated Acute Myeloid Leukemia No advantage for MRD-negative patients in first remission after induction, regardless of FLT3 ITD Dec 11, 2023
A Closer Look at the Approval of CRISPR/Cas9 Gene Therapy for Sickle Cell Disease This landmark event brings up broader considerations and implications for other diseases Dec 11, 2023
ASCT Tops CAR T-Cell Therapy for Relapsed LBCL in Complete Remission Better 2-year PFS, OS, but not applicable to primary refractory disease Dec 10, 2023
Lovo-Cel 'Life-Changing, Transformative' in Sickle Cell Disease Near complete resolution of pain events in patients, including adolescents Dec 10, 2023
AI and Breast Cancer Screening; Cancer After Treatment for Sickle Cell Also in TTHealthWatch: mail-in cervical cancer screening kits Dec 09, 2023 podcast
Milestone Gene Therapies for Sickle Cell Disease Greenlit by FDA Casgevy and Lyfgenia approved for one-time treatment of sickle cell disease Dec 08, 2023
FDA Approves Oral Factor B Inhibitor for Paroxysmal Nocturnal Hemoglobinuria Iptacopan tops C5 Inhibitors for sustained hemoglobin levels, eliminating need for transfusion Dec 06, 2023
Rituximab Maintenance Boosts Survival for Older Adults With MRD-Negative MCL Patients with treatment-sensitive disease may benefit most from continued treatment, says expert Dec 05, 2023
Novel Therapy Reduced Transfusion Dependence in Lower-Risk MDS 40% of patients treated with imetelstat were transfusion-free for at least 8 weeks Dec 04, 2023
Non-Covalent BTK Inhibitor Approved for CLL Response rates with pirtobrutinib reached 72% in heavily pretreated patient population Dec 04, 2023
FDA Investigating 'Serious Risk' of Malignancy After CAR-T Therapy Applies to all approved therapies, but benefits still outweigh risks, agency says Nov 28, 2023
Apixaban Prophylaxis Fails to Reduce Clots in Pediatric ALL However, it may benefit children at increased risk of thrombosis Nov 20, 2023
Alteplase Not Harmful in NOAC Users, Even in a More Bleeding-Prone Cohort No excess brain bleeds in an Asian population receiving lytic therapy for stroke Nov 20, 2023
Opioid Doc Sentenced; World's First Sickle Cell Gene Tx; FTC Warns Diet Influencers Health news and commentary from around the Web gathered by MedPage Today staff Nov 17, 2023
FDA Panel: Tolerating Approval Outliers Would Set 'Dangerous Precedent' No easy answers for two drugs for rare lymphoma on long cruise with accelerated approval Nov 16, 2023
FDA OKs Product to Thwart Bloodstream Infections During Dialysis Taurolidine-heparin solution reduced infections by 71% versus heparin alone Nov 15, 2023
Lymphoma Drug Copanlisib to Be Pulled From U.S. Market Failed confirmatory trial takes down another PI3K inhibitor Nov 14, 2023
First Treatment Approved for Genetic Clotting Disorder Adzynma indicated as prophylactic or on-demand enzyme replacement therapy in cTTP Nov 10, 2023
Vitamin D for Neuropathy; Good & Bad News for CAR-T; New Labeling for Surgical Mesh News, features, and commentary about cancer-related issues Nov 10, 2023
Wearables as Cancer Monitors; No China Price Break; Cancer Mystery in Appalachia News, features, and commentary about cancer-related issues Nov 03, 2023
Potential Cure for Sickle Cell Clears Hurdle for Approval FDA advisors suggest the benefits of gene therapy outweigh risks of off-target editing Oct 31, 2023
FDA Reviewers Question Safety of Sickle Cell Gene Therapy Efficacy results "strongly positive," but unintended off-target effects a question Oct 30, 2023
Soap to Fight Skin Cancer; $1,000 Early Cancer Detection Test; FDA Approval in MDS News, features, and commentary about cancer-related issues Oct 27, 2023
Quad Regimen for High-Risk Myeloma Produces High Rates of Durable MRD Negativity Two-thirds of transplant-eligible patients met endpoint with isatuximab/KRd Oct 19, 2023
Lonely Cancer Deaths; Virtual Reality for Pain; 3D Models May Improve Treatment News, features, and commentary about cancer-related issues Oct 19, 2023
Emicizumab Can Delay Immunosuppressive Tx in Acquired Hemophilia A "Strategy will probably be practice-changing," says expert Oct 18, 2023
Hemoglobin Targets a Good Idea for Massively Transfused Patients Outcomes improved with values approaching 10 g/dL Oct 16, 2023
Cryoprecipitate, REBOA Flop for Improving Major Hemorrhage Outcomes The first randomized trials of both approaches failed Oct 13, 2023
Rare Lung Bleeds Cluster in DOAC Users, Implications Unclear Pattern found in diffuse alveolar hemorrhage reports in FAERS Oct 11, 2023
Chemo Shortage: 'Paycheck to Paycheck'; Cancer Blood Test Shines; Struggling to Live News, features, and commentary about cancer-related issues Oct 06, 2023
ABIM CEO Retirement Comes Amid Wave of Criticism Richard Baron, MD, plans to step down as pushback against MOC grows Oct 02, 2023
IV Immunoglobulin May Cut Infection Risk of Anti-BCMA Agents for Myeloma Small retrospective study finds fewer severe infections during periods of replacement therapy Sep 29, 2023
Cancer Drug Shortages for Kids; Pharma Agrees to Price Talks; Catch-Up on Screening News, features, and commentary about cancer-related issues Sep 28, 2023
Frontline Combo Yields High Remission Rate in Hairy Cell Leukemia And almost all complete responders in small trial achieved MRD negativity Sep 25, 2023
TikTok Dinged for Misinformation; BRCA Risk Overestimated; Cheers for Oncology News, features, and commentary about cancer-related issues Sep 21, 2023
Another Win for Biomarker-Driven Thromboprophylaxis for Patients With Cancer Threefold risk reduction with enoxaparin in high-risk gastrointestinal, lung cancers Sep 21, 2023
FDA Approves JAK Inhibitor That Addresses Anemia in Myelofibrosis In a phase III trial, momelotinib reduced anemia, constitutional symptoms, and splenomegaly Sep 18, 2023
Weight-Loss Surgery Tied to Lower Blood Cancer Risk in Women Consider surgery for primary prevention in people with obesity, researchers suggest Sep 15, 2023
