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Duchenne Drug Fails Confirmatory Trial; COVID Brain Changes; First-Seizure Clinics

— News and commentary from the world of neurology and neuroscience

MedpageToday
Neuro Break over a computer rendering of neurons.

Preliminary data showed that viltolarsen (Viltepso), an exon-skipping drug that won accelerated approval to treat Duchenne muscular dystrophy in 2020, , NS Pharma said.

NG2 glia may by inhibiting prostaglandin E2 signaling from microglia to neurons, lab and animal studies suggested. (Nature Neuroscience)

An artificial-intelligence system coupled with a brain implant from a bilingual patient with paralysis into either Spanish or English words. (Nature Biomedical Engineering)

A resting-state functional MRI study in China demonstrated in COVID survivors versus healthy controls. (Lancet Regional Health-Western Pacific)

Multiple sclerosis with combination of the central vein sign, paramagnetic rim lesions, and cortical lesions. (Neurology: Neuroimmunology and Neuroinflammation)

A from the PsychENCODE consortium mapped gene regulation networks in autism, schizophrenia, bipolar disorder, and other conditions. (Science)

Otsuka Pharmaceutical a potential treatment for agitation associated with Alzheimer's dementia, after a phase III trial missed its primary endpoint.

Urolithin A and restored mitophagy and lysosomal functions. (Alzheimer's & Dementia)

And in an Alzheimer's mouse model altered glial activation and amyloid compaction. (Nature Neuroscience)

Progression on the Clinical Dementia Rating scale and cognitive functioning measures would stop driving. (Neurology)

A network meta-analysis supported multimodal interventions for in amyotrophic lateral sclerosis, with an emphasis on exercise. (Scientific Reports)

Patients who attended a in Australia had fewer emergency department visits and hospital admissions, a retrospective study showed. (JAMA Neurology)

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more.