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Alzheimer's Disease

News, opinions and meeting coverage in psychiatry.

The packaging and blister packs of Ritalin (methylphenidate)

Stimulant Reduces Apathy in Alzheimer's Disease

Twice daily methylphenidate showed modest effect size

A close up of a man's white rubber gloved hand picking up a bullet shell from the floor with tweezers.

Preventing Gun Violence in Patients With Dementia

Gun safety advocate Emmy Betz, MD, MPH, offers advice

A computer rendering of beta-amyloid protein forming plaques and collecting between neurons.

Amyloid Tipping Point Helps Predict Alzheimer's Dementia Onset

Algorithm requires only one PET scan and age

Feared ARNI Effect on Cognition Hasn't Come to Fruition

Neurocognitive protection by sacubitril/valsartan suggested instead by observational study

A computer rendering of a heart cross section with implanted left ventricular assist device

Some Reassurance on Cognition in People With Older LVADs

Will newer devices look even better for neurological outcomes?

A technician prepares blood samples for mass spectrometry

Blood Test Discerns Alzheimer's From Other Dementia With High Accuracy

Plasma p-tau moves another step closer to clinical use

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Driving Patterns Pinpoint Early Alzheimer's Disease

Subtle shifts in on-road behavior suggest GPS-based biomarkers may have merit

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

COVID-19: Persistent Cognitive Effects, Uptick in Alzheimer's Biomarkers

Findings link cognitive impairment and long-lasting anosmia

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

Epic's AI Fail; Controversial Alzheimer's Marketing; No Good COVID Drugs

This past week in healthcare investigations

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Aducanumab: What to Know If You Prescribe

Recommendations may change when trial data are published

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Better Air, Better Brains

Reducing air pollution tied to lower dementia risk, slower cognitive decline

A stressed looking senior woman next to a bottle of Nuplazid (pimavanserin) capsules.

Staying on Pimavanserin Cut Dementia-Related Psychosis Relapse

However, late-stage trial couldn't separate efficacy in dementia subtypes

A senior woman talks on her smartphone at home.

Phone Calls Spot Early Alzheimer's

Predictive model identified vocal features of dementia patients from everyday speech

The YouTube video thumbnail with Dr. Zubin Damania and Vinay Prasad, MD, MPH, and the words IVERMECTIN& Aducanumab?

Ivermectin and Aducanumab: Do They Work?

ZDoggMD and Vinay Prasad, MD, MPH, analyze the evidence

The vial and packaging of Aduhelm (aducanumab) for injection with blurred prescribing information in the background.

Alzheimer's Aducanumab Prescribing Information Changes

"We as neurologists need a strategy to advise our patients," experts say

A chart showing estrogen levels in a female silhouette from age 25-80

Alzheimer's Biomarkers Tied to Endogenous Estrogen Exposure in Women

Longer reproductive period linked to amyloid, p-tau in cognitively normal older women

A mature person with Down syndrome draws in an activity book.

APOE Gene Influences Alzheimer's Symptoms, Biomarkers in Down Syndrome

Earlier Alzheimer's changes seen in APOE4 carriers

A computer rendering of the release of cytokines.

Two Inflammatory Proteins Linked With Slower Cognitive Decline

Surprise finding ties plasma cytokine levels with Alzheimer's biomarkers and cognition

An FDA APPROVED seal over a photo of prescription bottles on a shelf

The FDA Is Failing the American People

The agency's recent decision to approve aducanumab offers more evidence of a broken system

A microscopy of Neurofibrillary tangles in the Hippocampus of an old person with Alzheimer-related pathology.

Alzheimer's Tau Vaccine Shows Immune Response, Safety

Exploratory, post hoc analyses hint at plasma NfL changes, and in some, slower cognitive decline

A photo collage of a wall clock and a portrait of a senior man staring into space and disintegrating into particles.

Cognitive Clock Predicts Brain Health

Brain age forecasts outcomes better than chronological age

A computer rendering of phosphorylation of tau proteins

Simple Tool Predicts Individual Alzheimer's Risk

Blood and quick cognitive tests boost accuracy to 90%

A photo of Daniel Gibbs, MD, PhD, next to his book A Tattoo on My Brain

A Neurologist Faces His Alzheimer's Disease

"I'm in the ring with the tiger," says Daniel Gibbs

A computer rendering of beta-amyloid protein clumping and tau protein accumulating in a brain with Alzheimer’s disease.

Defining Alzheimer's: Should Cognitively Unimpaired People Be Included?

A definition that works for research is not right for the clinic, experts argue

APA over an illustration of a red hand pulling a tangled thread from a woman’s head

Dissolving Film Quells Agitation in Schizophrenia, Bipolar Disorder

Improvements seen in 30 minutes or less with investigational oral agent

A mature businessman rests his chin on his handcuffed hands

Four Sentenced in Mental Health Center Scam

Heads of a Houston healthcare chain will go to prison for kickbacks, mental healthcare fraud

AAN over a computer rendering of synapses signaling

Alzheimer's Aducanumab Redosing Study Underway

Nearly 1,400 patients whose treatment was stopped when trials were halted have enrolled

A mother sits next to her sad looking young daughter on the couch

In Depression, the Apple Doesn't Fall Far From the Tree

Study shows kids have increased depression risk with family history

AAN over a computer rendering of synapses signaling

Blood-Based Markers Tied to Brain Cell and Memory Loss

Another step closer to clinical utility for tracking neurodegeneration

Illustration of a brain shaped maze.

New ADHD Drug OK'd; Pimavanserin Rejected for Dementia Psychosis

News and commentary from the psychiatry world

A man wearing a party hat sits alone at a table in front of a birthday cake

Middle-Age Loneliness Linked to Alzheimer's Disease

Relationship varied, depending on whether loneliness persisted

Vials of Leukine (sargramostim) sit atop their packaging

Marrow Cell Stimulator to Treat Alzheimer's Disease?

Unusual approach pans out in mid-stage trial

Brain scan images with NeuroBreak in the center.

Bacon and Dementia Risk; Zinc Fingers and Tau; Older Adults Light Up

News and commentary from the world of neurology and neuroscience

Cartoon image of a man holding the back of his ear to hear better

'They Stopped Treating and the Effect Persisted': What We Heard This Week

Quotable quotes from MedPage Today's sources

Four portraits of an anguished man blended together

High Prevalence of Early-Onset Dementia in Schizophrenia Patients

More than a quarter had a dementia diagnosis by age 66

A close up of a senior man and woman embracing, her hand on his cheek

Ethics Consult: Does Dementia Preclude 'Consent' to Sex? MD/JD Weighs In

You voted, now see the results and an expert's discussion

AAN over several MRI scans of a brain

Alzheimer's May Start Sooner for People With Anxiety, Depression History

Psychiatric disorders could have additive effects on AD pathophysiology, study suggests

Brain scan images with NeuroBreak in the center.

Sleep-Dementia Link; Neanderthal Mini-Brains; MS Tx and COVID Vax

News and commentary from the world of neurology and neuroscience

A smiling woman who has just turned 100 points at her head

High Cognitive Performance at Age 100

Some centenarians show resilience to cognitive decline, despite brain pathology

An illustration of a person's thoughts and memories connected to their brain

Primary Progressive Aphasia in Alzheimer's Doesn't Foretell Memory Loss

No memory decline over more than 2 years in small study, though speech deficits grew

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