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Dementia

News, opinions and meeting coverage in psychiatry.

Illustration of a brain shaped maze.

New Caplyta Doses OK'd; ECT Effective Against Suicide; Antidepressants Flop for QoL

News and commentary from the psychiatry world

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Is Alzheimer's Risk Lower With TNF Inhibitors?

For arthritis patients with cardiovascular disease, the answer may be yes

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Memory Enhancer Succeeds in Phase II Alzheimer's Trial

Novel NMDA-targeted drug would expand options for symptomatic treatment

A photo of the vial and packaging of Aduhelm.

Aducanumab Data Finally Published, but Alzheimer's Experts Spot Problems

Questions raised about secondary endpoints

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Left Atrial Disease Linked to Incident Dementia

Echocardiographic findings suggest more therapeutic targets for dementia

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Lithium Linked to Dementia Prevention

Study found lower risk of developing Alzheimer's, vascular dementia

A senior woman sitting in bed massages her toes.

Peripheral Nerve Problems Tied to Later Dementia

Findings may indicate shared susceptibility to neurodegeneration

Medical staff members from Jiangsu Province work at an ICU ward of the First Hospital of Wuhan City in Wuhan, central China

Cognitive Effects Persist in Older COVID Patients

Long-term cognitive decline common after SARS-CoV-2 hospitalization

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Owning a Pet May Protect Cognitive Health

Strongest benefit seen for long-term pet owners

Illustration of a brain shaped maze.

Pimavanserin Resubmitted to FDA; APA's New President Elect; Bipolar Market Slowing

News and commentary from the psychiatry world

A senior man sits in a chair next to his bed and looks out the window.

Loneliness May Triple Dementia Risk

Even without dementia, lonely feelings linked with brain changes

A cross section slice of a brain with Alzheimer’s disease

COVID Brain Changes Show Parallels With Alzheimer's Disease

Findings may point to potential mechanism for brain fog in people with long COVID

A blue rubber gloved hand holds a test tube of blood in front of a brain MRI

Blood Biomarkers May Distinguish Dementia Disorders

Plasma levels show diagnostic, prognostic performance in varying dementia types

A blood pressure cuff, a stethoscope and a spilled prescription bottle of green pills.

Mixing and Matching BP Meds? Consider the Implications for Dementia

SPRINT analysis favors certain classes of antihypertensives

An illustration depicting Alzheimer’s disease with amyloid plaques forming between neurons

Alzheimer's Drugs Race to FDA

After aducanumab, drug companies pivot to use the accelerated approval pathway

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Can Viagra Prevent Alzheimer's?

Sildenafil shows potential for drug repurposing

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Dementia Tied to Resting Heart Rate

Findings persist even after accounting for cardiovascular disease

AHA over a computer rendering of the heart.

Aspirin Flops Again for Dementia Prevention

ASCEND trial sides with ASPREE, but can't rule out some potential benefit

AHA over a computer rendering of the heart.

Two Anticoagulants -- When Used Correctly -- Similarly Protective Against Dementia

GIRAF trial tested warfarin versus dabigatran in older Afib patients

EASD over an illustration of a person's hand and blood glucose monitor and other icons associated with diabetes.

Healthy Lifestyle Keeps Dementia at Bay in Patients With Diabetes

Maintaining control of risk factors neutralized excess dementia risk

The packaging and blister packs of Ritalin (methylphenidate)

Stimulant Reduces Apathy in Alzheimer's Disease

Twice daily methylphenidate showed modest effect size

A close up of a man's white rubber gloved hand picking up a bullet shell from the floor with tweezers.

Preventing Gun Violence in Patients With Dementia

Gun safety advocate Emmy Betz, MD, MPH, offers advice

A computer rendering of beta-amyloid protein forming plaques and collecting between neurons.

Amyloid Tipping Point Helps Predict Alzheimer's Dementia Onset

Algorithm requires only one PET scan and age

Feared ARNI Effect on Cognition Hasn't Come to Fruition

Neurocognitive protection by sacubitril/valsartan suggested instead by observational study

A computer rendering of a heart cross section with implanted left ventricular assist device

Some Reassurance on Cognition in People With Older LVADs

Will newer devices look even better for neurological outcomes?

Illustration of a brain shaped maze.

Twice-Yearly Schizophrenia Tx OK'd; Austedo Effective Long-Term; $$ for Sobriety

News and commentary from the psychiatry world

A technician prepares blood samples for mass spectrometry

Blood Test Discerns Alzheimer's From Other Dementia With High Accuracy

Plasma p-tau moves another step closer to clinical use

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Driving Patterns Pinpoint Early Alzheimer's Disease

Subtle shifts in on-road behavior suggest GPS-based biomarkers may have merit

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

COVID-19: Persistent Cognitive Effects, Uptick in Alzheimer's Biomarkers

Findings link cognitive impairment and long-lasting anosmia

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Aducanumab: What to Know If You Prescribe

Recommendations may change when trial data are published

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Better Air, Better Brains

Reducing air pollution tied to lower dementia risk, slower cognitive decline

Illustration of a brain shaped maze.

Drug Overdoses Spike; Shock Therapy Effective; Psychiatrist Charged for 'Pill-Mill'

News and commentary from the psychiatry world

A stressed looking senior woman next to a bottle of Nuplazid (pimavanserin) capsules.

Staying on Pimavanserin Cut Dementia-Related Psychosis Relapse

However, late-stage trial couldn't separate efficacy in dementia subtypes

A senior woman talks on her smartphone at home.

Phone Calls Spot Early Alzheimer's

Predictive model identified vocal features of dementia patients from everyday speech

A sad and distressed looking young woman curled up on a couch holding a smartphone.

The Mental Health Toll of Not Matching

Reports of suicides and unprecedented social media dialogue have turned a spotlight on the issue

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Two Inflammatory Proteins Linked With Slower Cognitive Decline

Surprise finding ties plasma cytokine levels with Alzheimer's biomarkers and cognition

SLEEP over a conceptual image of dreaming: a woman in a bed floating in the clouds with birds.

Sleep Disorders Tied to Dementia in Patients With TBI

Study evaluates outcomes by sex, independently of other dementia risks

SLEEP over a conceptual image of dreaming: a woman in a bed floating in the clouds with birds.

Trouble Falling Asleep Predicts Later Cognitive Impairment

Depression and vascular disease may play roles

A photo collage of a wall clock and a portrait of a senior man staring into space and disintegrating into particles.

Cognitive Clock Predicts Brain Health

Brain age forecasts outcomes better than chronological age

A computer rendering of phosphorylation of tau proteins

Simple Tool Predicts Individual Alzheimer's Risk

Blood and quick cognitive tests boost accuracy to 90%

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