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Oncology/Hematology

News, opinions and meeting coverage in oncology/hematology.

Experts Debate AQUILA Trial Findings in Smoldering Multiple Myeloma

Phase III trial sparks discussion on defining and managing high-risk smoldering myeloma

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Randy Moss Has Cancer; Nancy Pelosi's Surgery; Possible Bird Flu Case Hospitalized

Health news and commentary gathered by MedPage Today staff

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A Setback for TNBC Monitoring With Circulating Tumor DNA in ZEST Trial

Study was stopped early due to enrollment issues, but lessons can still be learned

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Homing in on Anthracyclines' High-Risk Niche in Early Breast Cancer

Significant improvement in 5-year distant relapse-free interval with higher risk score

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Better Quality of Life With RT vs Endocrine Therapy in Older Breast Cancer Patients

Radiotherapy also resulted in fewer treatment-related adverse events

Onco Break over a computer rendering of a cancer cell.

Hair Growth After Cancer; 'Global' Early-Onset CRC; Retifanlimab Boosts OS in NSCLC

News, features, and commentary about cancer-related issues

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No Apparent Harm From Omitting Lymph Node Dissection in Selected Breast Cancers

Nearly identical 5-year outcomes with no surgery, sentinel lymph node biopsy

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Palbociclib Regimen Yields 'Incredible' PFS Gain in Metastatic Breast Cancer

Study results are "historic," expert says

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Risk-Reducing Surgery May Benefit BRCA Carriers With Early-Onset Breast Cancer

Lower rates of mortality and cancer recurrence with mastectomy, salpingo-oophorectomy

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Skip Surgery for DCIS in Favor of Active Monitoring?

No invasive cancer increase at 2 years, but editorialists say data don't back active monitoring

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Lung Cancer Drug Osimertinib Tied to Cardiac Events, Even in Low-Risk Patients

Signal largely driven by newly emerging arrhythmias

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Industry Clinic • Ad Insights

Subcutaneous Cancer Immunotherapies Provide New Options for Physicians and Patients

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Pulled Myeloma Drug Improves Survival in Trial

DREAMM-7 findings help pave the way for Blenrep's return

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Oral SERD Impresses in Advanced Breast Cancer With ESR1 Mutations

However, imlunestrant failed to improve PFS among entire trial population

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One CAR T-Cell Therapy for Multiple Myeloma Tops Another in Propensity Matched Study

Higher response rate, PFS, OS with cilta-cel, but ide-cel had lower rate of severe toxicity

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Cancer Patients Who Completed Medication Survey Received More Help From Pharmacists

Study assessed pharmacist interventions for adverse events

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Pirtobrutinib Delays Progression in CLL Already Treated With a BTK Inhibitor

But no overall survival benefit seen in confirmatory trial

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Tafasitamab-Based Combination Boosts PFS in Relapsed/Refractory Follicular Lymphoma

Benefit seen in all prespecified subgroups, including high-risk patients

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USPSTF Plans Changes to Cervical Cancer Screening Recommendations

Self-collected HPV testing is a new addition

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Generous Blood Transfusions Not Beneficial for Some With Burst Brain Aneurysms

SAHARA rounds out this year's notable trials on blood transfusions in critically ill patients

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Benefits of Transplant for Pediatric Sickle Cell Disease Add Up a Decade Later

Better disease outcomes, measures of cognition, and quality-of-life vs standard care, study finds

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Transplantation Fails to Improve Survival in Mantle Cell Lymphoma

New standard of care for patients in first remission?

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Lentiviral Gene Therapy Shows Promise in Severe Hemophilia A

Increased factor VIII levels to mild or moderate range, with annualized bleeding rate of zero

2024 YEAR IN REVIEW CLL over a computer rendering of CAR T cell therapy in chronic lymphocytic leukemia.

Year in Review: Chronic Lymphocytic Leukemia

Top news in 2024 included the first CAR-T approval for CLL, triplet regimens, and more

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Industry Clinic • Ad Insights

Alecensa (alectinib) Offers Hope for Certain Patients With ALK Positive NSCLC

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Hydroxyurea Shows Some Benefits in Milder Sickle Cell Disease

Treatment tied to fewer vaso-occlusive pain events, hospitalizations versus placebo

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Fixed-Duration Oral Doublet for Fit CLL Wins in Frontline Setting

AMPLIFY trial paves the way for FDA approval of acalabrutinib plus venetoclax

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Treatment of Smoldering Myeloma Cuts Progression Rate in Half

Daratumumab significantly improved PFS, OS, but identity of high-risk population remains elusive

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Promising Results With Epcoritamab Monotherapy in Relapsed/Refractory CLL

Complete responses seen in 43% of patients in expansion cohort of EPCORE CLL-1 study

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Novel BTK Inhibitor Succeeds in Heavily Pretreated Immune Thrombocytopenia

Rilzabrutinib specifically designed to reduce platelet-targeting autoantibodies

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Loncastuximab-Rituximab Boosts Response Rates in R/R Follicular Lymphoma

Two-thirds of phase II patients had a complete response at 12 weeks of treatment

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Dietary Intervention Shows Promise in Blood Cancers

High-fiber diets tied to improved outcomes in stem-cell transplants, slowing myeloma precursors

Texting to Improve Adherence to CVD Medications; Detecting Maternal Cancers

Also in TTHealthWatch: U.S. drug prices under Medicare's price negotiation system

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Dual Targeted CAR-T Yields 99% Response Rate in Pediatric ALL

Cytokine release syndrome developed in all patients, including grade 3/4 events in nearly half

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New Standard for Newly Diagnosed Pediatric B-Cell Acute Lymphoblastic Leukemia

Blinatumomab consolidation reduced risk of relapse by 61% versus chemotherapy alone

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Eltrombopag Improves Outcomes in Kids With Newly Diagnosed ITP

Drug may potentially "transform" approach to upfront treatment, investigator says

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Experts Wrestle Over Uses of PFAS During Senate Hearing

Industry witness warns of unintended consequences of blanket bans

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Self-Pay, AI-Enhanced Breast Cancer Screening Detected More Cancers

Overall cancer detection rate was about 43% higher versus women who chose not to participate

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AI Breath Test IDs Cancers; More Grief for Prior Auth; Imatinib Discoverer Resigns

News, features, and commentary about cancer-related issues

A photo of a stethoscope in the center of a circle of variously colored cancer ribbons.

Nearly 6 Million Deaths From Five Major Cancer Types Averted Since 1975

Prevention and screening efforts accounted for 80% of those averted deaths

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