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Oncology/Hematology

News, opinions and meeting coverage in oncology/hematology.

A photo of patients receiving chemotherapy in an infusion clinic.

Study Supports More Inclusive Clinical Trials With Broader Eligibility Criteria

No difference in adverse events, clinical benefit, OS for patients with or without waivers

A photo of a female teen wearing a head scarf being comforted by her mother.

Young Cervical Cancer, Leukemia Survivors at Greater Risk of Obstetric Complications

Population-based study suggests reassurance for most, high-risk strategies for some

CAR T-Cell Therapy in Functional High-Risk Multiple Myeloma

Joseph Mikhael, MD, leads a discussion on the subgroup analysis of CARTITUDE-4

A photo of a blue rubber gloved hand holding a test tube of blood labeled: PSA Test.

What's a Normal PSA Value for Transgender Women on Estrogen Therapy?

Study suggests threshold is too high to identify risk of prostate cancer in this population

A photo of a female technician preparing a chemotherapy treatment in a glove box.

Oncology Drug Shortages Persist, but Continue to Evolve

Supply-chain issues, unrealistically low prices for generics, hoarding, other factors to blame

A close up photo of the hands of an adolescent receiving infusion therapy.

Temsirolimus Plus Chemotherapy Fails in Rare Childhood Cancer

Adding the mTOR inhibitor didn't improve EFS in intermediate-risk rhabdomyosarcoma

A computer rendering of a liver under a red umbrella.

Real-World Analysis Identifies Meds Tied to Higher Risk of Liver Injury

Case reports may not be as reliable, researchers say

Combo of Approved Agents Active in High-Risk Large B-Cell Lymphoma

Our panel of experts discusses mosunetuzumab/polatuzumab vedotin for relapsed/refractory patients

A close up photo of an acupuncture needle between a woman’s fingers.

Acupuncture Reduced Hot Flashes Related to Endocrine Therapy for Breast Cancer

64% of women reported at least a 50% reduction in hot flash frequency and severity

FDA APPROVED crovalimab (Piasky) over a computer rendering of blood flowing inside a vessel.

Subcutaneous C5 Inhibitor Approved for PNH

Longer-acting crovalimab designed for more sustained effect and less treatment burden

Treating Advanced Breast Cancer After Progression on CDK4/6 Inhibitors

Results from postMONARCH offer one path

A photo of the HealthCare.gov website.

Court: Some Employers Can Exclude PrEP, Cancer Screenings From Insurance Coverage

Not all preventive care recommended by the USPSTF is threatened by the narrow ruling, however

FDA APPROVED adagrasib (Krazati) over a computer rendering of colorectal cancer.

Adagrasib Wins Accelerated Approval for KRAS-Mutant Colorectal Cancer

KRAS inhibitor plus cetuximab achieved 34% response rate, 85% disease control in early trial

ASTRO Guideline Addresses Specifics of HPV-Associated Oropharyngeal Cancer

Clinical landscape has shifted away from traditional risks for H&N cancer to HPV predominance

A computer rendering of a meningioma.

ALK Inhibitor Shows Promise in Rare, Progressive Tumor Types

Phase II study found brigatinib exceeded historical control by shrinking 10% of targeted tumors

Onco Break over a computer rendering of a cancer cell.

EU Adds CAR-T Warning; New Blincyto Indication; Good News in Pancreatic Cancer

News, features, and commentary about cancer-related issues

A computer rendering of a transparent body with a tumor in the lungs highlighted.

Anti-PD-L1 Plus Targeted Agent No Better Than Chemo for Resistant NSCLC

No significant difference between atezolizumab-cabozantinib, docetaxel for OS, PFS, response

EHA over a photo of IFEMA Madrid in Spain.

Glofitamab Regimen Improves Survival in DLBCL

Granted accelerated approval last year, bispecific antibody passes its confirmatory test

Using MRD Status to Deescalate Multiple Myeloma Therapy

Joseph Mikhael, MD, leads a discussion on the findings of the MRD2STOP study

A computer rendering of diffuse large B-cell lymphoma cells.

Multidrug Regimen Could Change Treatment Landscape for Relapsed/Refractory DLBCL

High-rate of durable responses with ViPOR sparks talk of supplanting CAR-T in second line

A computer rendering of monoclonal antibodies.

Novel Anti-CD38 Drug Shows Promise for Immune Thrombocytopenia

"Rapid and sustained" efficacy in 95% of pretreated patients in small trial

EHA over a photo of IFEMA Madrid in Spain.

Three-Drug Regimens Make Case for a Role in Untreated and Relapsed/Refractory CLL

Undetectable MRD rates of 90% or higher, PFS of 7 years or more

FDA APPROVED durvalumab (Imfinzi), pembrolizumab (Keytruda) over an illustration of endometrial cancer.

Two New Immunotherapy-Chemo Options Approved for Endometrial Cancer

New indications for pembrolizumab and durvalumab in advanced disease

EHA over a photo of IFEMA Madrid in Spain.

New Standard of Care in High-Risk Acute Promyelocytic Leukemia?

All-trans retinoic acid plus arsenic trioxide and idarubicin improved EFS over standard

A photo of the state flag of California.

I Tried to Protect My Mother From Dying in Pain. The Law Robbed Her of That Dignity.

It's time to clear the roadblocks to Medical Aid in Dying in the U.S.

Train Eyes So Myopia Doesn't Get Worse? Nurse Intervention for BP Post-Stroke

Also in TTHealthWatch: cancers subsequent to CAR-T therapy

EHA over a photo of IFEMA Madrid in Spain.

Atezolizumab Consolidation Impresses in High-Risk DLBCL

Will 2-year DFS of 88%, OS of 96% renew interest in checkpoint inhibitor consolidation?

A photo of Kate Middleton

Kate Middleton Gives Cancer Update

Princess of Wales says she's making "good progress" in treatment

Adding Isatuximab to Standard Backbone Prolongs PFS in Myeloma

Joseph Mikhael, MD, leads a roundtable discussion on two positive phase III trials from ASCO

A close up photo of a woman smoking a cigarette.

Early Menopause Tied to Higher Risk of Respiratory Mortality

Greatest risk observed for women with bilateral oophorectomy

Onco Break over a computer rendering of a cancer cell.

Upping Immunotherapy Activity; A Win for Lung Screening; Looming Drug Price Break?

News, features, and commentary about cancer-related issues

An MRI image of the prostate gland.

AI System Beats Radiologists in Detecting Clinically Significant Prostate Cancer

AI detected 6.8% more clinically significant cancers, 20% fewer indolent cancers

A photo of an open tanning bed.

Tanning Salons Are Overdue for a Regulatory Burn

In the meantime, don't forget to educate patients on the risks

A computer rendering of CAR T cell therapy in Diffuse large B-cell lymphoma

New Clues to Origin of T-Cell Lymphoma After CAR-T Therapy

Co-mutations, viral link, potential common susceptibility emerge from two studies

A photo of Alunbrig (brigatinib) tablets.

Brigatinib Makes Its Case for ALK-Positive ALCL in Small Study

Second-gen ALK inhibitor induces high response rate, associated with impressive survival

A photo of the vials and packaging of Irinotecan hydrochloride.

Nanoliposomal Irinotecan Fails to Boost Survival in Treated Advanced Biliary Cancer

No difference in PFS, median OS favored control group

A computer rendering of a lung tumor.

Another KRAS Inhibitor Scores an Early Win in Advanced Non-Small Cell Lung Cancer

Half of patients responded, but editorialists call for new directions in therapy development

A photo through the doorway of the CT scanning room.

Middle-Age Man Presents With Necrotizing Mass on Nose

Rare condition can be deadly without early diagnosis and treatment

A scanning electron microscope image of a dendritic cell

Dendritic Cell Therapy Offers No Survival Advantage in Pleural Mesothelioma

Immunotherapy may have been given too late, researchers suggested

An advertisement for lung cancer screening on the back of a kiosk in New York City.

Lung Cancer Screening Rates Remain Low in the U.S., Especially in the South

But one study showed that patient navigation added to usual care may increase uptake

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